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doi: 10.4322/POLIMEROS020OV002 36 CookM

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Quercetin can block the HMGB1/RAGE/NF-B axis to inhibit the release of pro-inflammatory factors such as TNF- and IL-6, target the NLRP3 inflammasome to block the maturation of IL-1/IL-18, and restore the balance of immune cell apoptosis by upregulating miR-204 to inhibit the HIF1/NFATc2 axis and the Src-STAT3-NFAT pathway (Rajabi et al., 2020

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it exhibits anti-fibrotic effects by restraining HSC activation/proliferation [138]

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